If any portion of the tablet is left in the cup, add another 30 mL of water to the cup, swirl for at least 15 seconds, and using the same syringe, administer via the nasogastric or gastric feeding tube. For oral solution: one 2-L jug with powder contains 210 g PEG-3350, 5.6 g sodium chloride, 2.86 sodium bicarbonate, and 0.74 g potassium chloride.

Citrucel Orange Flavor Powder - Actions: Promotes elimination by providing additional fiber (bulk) to the diet. Adjust dosage daily to produce 2-3 soft stools.

Sulfate salts provide sulfate anions, which are poorly absorbed. ◇ Unlabeled clinical use. The beads will remain visible and will not dissolve. Glycerin reduces fluid in the cornea via its osmotic action and clears corneal haze. Also contraindicated in patients with anuria, severe dehydration, frank or impending acute pulmonary edema, severe

Supplied: Solution, oral: 290 mg/5 mL (300 mL).

• Safety and effectiveness of ophthalmic glycerin solutions in children haven’t been established.

INDICATIONS AND USAGE: SYMPROIC is an opioid antagonist indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain. Contraindicated in patients hypersensitive to drug. Mechanism of Action:Lubiprostone is a locally acting chloride channel activator that enhances a chloride-rich intestinal fluid secretion without altering sodium and potassium concentrations in the serum.

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INDICATIONS AND USAGE:   Suclear is a combination of osmotic laxatives and indicated for cleansing of the colon in preparation for colonoscopy in adults.DOSAGE AND ADMINISTRATION Suclear, supplied as oral solution (Dose 1) and for oral solution (Dose 2), must be reconstituted with cool water before use. Adults: 1 to 2 drops of ophthalmic solution topically before eye examination; 1 to 2 drops q 3 to 4 hours for corneal edema. of water or other clear liquid. Mechanism of Action Mineral oil coats the stool to help seal in water.

• Tell patient to lie down during and after administration to prevent or relieve headache.

administration, or both. abdomen. • Teach correct way to instill drops, and warn patient not to touch eye with dropper. Do not store the applesauce and beads for later use. trailer Linaclotide caused deaths in young juvenile mice.

Place one teaspoonful of applesauce at room temperature into a clean container.

1.2 Chronic Idiopathic Constipation (CIC) LINZESS is indicated in adults for the treatment of chronic idiopathic constipation (CIC).

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In animal models, plecanatide has been shown to increase fluid secretion into the gastrointestinal (GI) tract, accelerate intestinal transit, and cause changes in stool consistency.

David McAuley, Pharm.D. Copyright 2017 GlobalRPH - Web Development by, do not take more than directed unless advised by your doctor, 1 teaspoonful/dose for many sugar free or select concentrated products, Polyethylene glycol 3350 (miralax®) powder for solution, Prepopik ® (sodium picosulfate, magnesium oxide, and anhydrous citric acid), Psyllium (fiberall® , genfiber®, konsyl®, metamucil® ), Suclear® (na sulfate, potassium sulfate and mg sulfate oral soln; and peg-3350, HONcode standard for trust- worthy health, Study results: Underutilization of generics by U.S. Ophthalmologists.

Possible risks must be weighed against benefits. Fleet phospho-soda Each 5 mL of Fleet-Phospho-soda® contains 2.4 g monobasic sodium phosphate monohydrate and 0.9 g dibasic sodium phosphate heptahydrate in a stable, buffered aqueous solution.

Adults and children age 6 and older: 3 g as a suppository or 5 to 15 ml as an enema. Most common adverse reactions (incidence > 4%) in chronic idiopathic constipation are nausea, diarrhea, headache, abdominal pain, abdominal distension, and flatulence. %PDF-1.4 %����

Possible risks must be weighed against benefits.

Mechanism of Action: Plecanatide is structurally related to human uroguanylin, and similar to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Dave's note: (MAXIMUM DOSE) Some sources list the daily maximum as 25 grams which is equivalent to ~425 ml.

Both linaclotide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Patients with a Clcr <25 mL/minute should be monitored by serum magnesium levels. Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). membranes before during and after initiation of treatment Teach clients to from NUR 3191 at Nova Southeastern University

The osmotic effect of unabsorbed sulfate anions and the associated cations causes water to be retained within the gastrointestinal tract. • Commercially available solutions may be poured over ice and sipped through a straw. Side Effects. Based on these properties, the CNS penetration of naldemedine is expected to be negligible at the recommended dose levels, limiting the potential for interference with centrally-mediated opioid analgesia.

endstream endobj 293 0 obj <>/Size 273/Type/XRef>>stream 1] Treatment of chronic idiopathic constipation in adultsDose: 24 mcg taken twice daily orally with food and water.

Most common adverse reactions (incidence > 4%) in irritable bowel syndrome with constipation are nausea, diarrhea, and abdominal pain. Oral Administration in Applesauce: In a clean container, crush the TRULANCE tablet to a powder and mix with 1 teaspoonful of room temperature applesauce. INDICATIONS AND USAGE:  MOVANTIK (naloxegol) is an opioid antagonist indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain, HOW SUPPLIED:  Tablets: 12.5 mg and 25 mg. Avoid use of TRULANCE in patients 6 years to less than 18 years of age [see WARNINGS AND PRECAUTIONS (5.1), USE IN SPECIFIC POPULATIONS (8.4)]. Supplied: 748 mOsmol/45mL. Protect clothing - may have oil leakage from rectum.

Therefore, it is not necessary to consume all the beads to deliver the complete dose.

Do not store the bead-water mixture for future use.

Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).

PEG is also a largely unabsorbed osmotic agent which causes water to be retained within the gastrointestinal tract. • Tell patient to lie down during and after administration to prevent or relieve headache. Diuretics: May cause additive effects.

Mixing TRULANCE crushed tablets in other soft foods or in other liquids has not been tested. Rectal administration: 200 g (300 ml) diluted with 700 ml of H20 or NS - administer rectally via rectal balloon catheter and retain 30-60 minutes every 4-6 hours. Supplied: Gelatin capsules: 8 mcg and 24 mcg.

Sodium phosphate enema (Fleet's enema) Mechanism of Action Soften stool by increasing water content Distend distal colon inducing peristalsis Clinical Indications Usually reserved for treatment of fecal impaction.

0000003600 00000 n 0000002991 00000 n INDICATIONS AND USAGE: 1.1 Irritable Bowel Syndrome with Constipation (IBS-C) LINZESS (linaclotide) is indicated in adults for the treatment of irritable bowel syndrome with constipation (IBS-C).

x�b```�� R����x�b�@���� �J��F�� ��� +�� -�"`U�FM�����h��5�4�X&��n�����!�"�fb[ fg`p���@�l�;���!5H3�@� �s- • Use topical tetracaine hydrochloride or proparacaine before ophthalmic instillation to prevent discomfort. in ophthalmoscopy or gonioscopy.

Supplied: Rectal suppository: 10 mg. Tablet [enteric coated]: 5 mg. Dosing (Adults)Stool softener: Oral: 50-500 mg/day in 1-4 divided doses  [Onset of action:  12 - 72 hours] Rectal: Add 50-100 mg of docusate liquid to enema fluid (saline or water); give as retention or flushing enema. 2. hypophospha temia & hypocalcemia . Also used for reducing brain volume during neurosurgical procedures through oral administration, I.V.

Topically applied glycerin produces a hygroscopic (moisture-retaining) effect that reduces edema and improves visualization

• Use topical tetracaine hydrochloride or proparacaine before ophthalmic instillation to prevent discomfort.

HOW SUPPLIED: TRULANCE Tablets: 3 mg: white to off-white, plain, round tablet debossed with "SP" on one side and "3" for 3 mg on the other side. Hepatic Impairment: Amitiza has not been studied in patients who have hepatic impairment. 3.

• To prevent or relieve headache, have patient remain supine during and after oral administration. Swallow the entire mixture of beads and water immediately.

DOSAGE AND ADMINISTRATION: PDF 2.1 Administration Alteration of analgesic dosing regimen prior to initiating SYMPROIC is not required.

edema. xref • Instruct patient to report severe headache after oral dose. Discontinue SYMPROIC if treatment with the opioid pain medication is also discontinued. Naldemedine is also a substrate of the P-glycoprotein (P-gp) efflux transporter. Metabolic: mild hyperglycemia, mild glycosuria. • If excess glycerin is administered into eye, irrigate conjunctiva with sterile normal saline solution or water. Adults and children 12 years and older 1) Laxative: 15 to 45 mL. • Other uses include reducing ICP in patients with CVA, meningitis, encephalitis, Reye’s syndrome, or CNS trauma or tumors. 273 22

Reduction of intraocular pressure. these will counteract osmotic effects. Elevation of intracellular cGMP stimulates secretion of chloride and bicarbonate into the intestinal lumen, mainly through activation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, resulting in increased intestinal fluid and accelerated transit.

Due to the reduced permeability and increased efflux of naloxegol across the blood-brain barrier, related to P-gp substrate properties, the CNS penetration of naloxegol is expected to be negligible at the recommended dose levels limiting the potential for interference with centrally mediated opioid analgesia. [Onset of action: 15 - 30 minutes], Acute Hepatic encephalopathy or portosystemic encephalopathy (PSE): Adults: Oral: 20-30 g (30-45 ml) every 1-2 hours to induce rapid laxation.

Mix by gently swirling the tablet and water mixture for at least 10 seconds. After administering the bead-water mixture, flush nasogastric/gastric tube with a minimum of 10 mL of water.

MECHANISM OF ACTION — Reduces surface tension of the oil-water interface of the stool resulting in enhanced incorporation of water and fat allowing for stool softening.

cardiac decompensation, undiagnosed abdominal pain, vomiting, or other signs of appendicitis, fecal impaction, or acute surgical

Glycerin is a hyperosmotic laxative, which is given rectally, and it usually produces a bowel movement within 15 minutes to 1 hour.

Metabolism: About 80% metabolized in liver, 10% to 20% in kidneys.

Elevation in intracellular cGMP stimulates secretion of chloride and bicarbonate into the intestinal lumen, mainly through activation of the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel, resulting in increased intestinal fluid and accelerated transit.

Excretion: Excreted in feces and urine. DOSAGE AND ADMINISTRATION: 2.1 Recommended Dosage The recommended dosage of TRULANCE is 3 mg taken orally once daily.

0 Please review the latest applicable package insert for additional information and possible updates. Senokot-S Tablets: Each tablet contains 8.6 mg sennosides and 50 mg of docusate sodium], ----------------------------------------------Adjunct to sodium polystyrene sulfonate: 15 mL as 70% solution orally until diarrhea occurs (10-20 mL/2 hours) or 20-100 mL as an oral vehicle for the sodium polystyrene sulfonate resin, ----------------------------------------------.



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